Abstract
From the aqueous extract of the wood of Taxus yunnanensis, which showed cytochrome P450 3A4 (CYP3A4) inhibition, a new isoflavan [(3S,4R)-4'-hydroxy-6,3'-dimethoxyisoflavan-4-ol (1)], a new degraded lignan [2,3-bis(hydroxymethyl)-7-hydroxy-6-methoxy-1-tetralone (2)], and a new lignan [(7R)-7-hydroxytaxiresinol (3)] were isolated, together with nine known lignans. Among the isolates obtained, α-conidendrin (12) showed strong CYP3A4 inhibition with an IC(50) value of 0.2 μM.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Antioxidants / chemistry
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Antioxidants / isolation & purification*
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Antioxidants / pharmacology*
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Biphenyl Compounds / pharmacology
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Colletotrichum / chemistry*
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Cytochrome P-450 CYP3A
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Cytochrome P-450 CYP3A Inhibitors*
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Drug Screening Assays, Antitumor
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / isolation & purification*
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Free Radical Scavengers / pharmacology*
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Furans / chemistry
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Furans / isolation & purification*
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Furans / pharmacology*
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Hep G2 Cells
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Humans
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Isocoumarins / chemistry
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Isocoumarins / isolation & purification*
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Isocoumarins / pharmacology*
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Isoflavones / chemistry
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Isoflavones / isolation & purification*
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Isoflavones / pharmacology*
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Lignans / chemistry
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Lignans / isolation & purification*
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Lignans / pharmacology*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Picrates / pharmacology
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Taxus / microbiology
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Tetrahydronaphthalenes / chemistry
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Tetrahydronaphthalenes / isolation & purification*
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Tetrahydronaphthalenes / pharmacology*
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Wood / chemistry
Substances
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(3S,4R)-4'-hydroxy-6,3'-dimethoxyisoflavan-4-ol
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(7R)-7-hydroxytaxiresinol
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2,3-bis(hydroxymethyl)-7-hydroxy-6-methoxy-1-tetralone
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Antineoplastic Agents, Phytogenic
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Antioxidants
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Biphenyl Compounds
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Cytochrome P-450 CYP3A Inhibitors
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Free Radical Scavengers
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Furans
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Isocoumarins
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Isoflavones
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Lignans
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Picrates
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Tetrahydronaphthalenes
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conidendrin
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1,1-diphenyl-2-picrylhydrazyl
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Cytochrome P-450 CYP3A
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CYP3A4 protein, human